The Farncombe Family Digestive Health Research Institute, established in 2008 at McMaster University, aims to understand, treat, and cure chronic illnesses within and beyond the gut, focusing on the intestinal microbiota and its link to the brain. Using a multidisciplinary approach, the Institute bridges bench-to-bedside research, fosters clinician-scientist collaborations, and trains future leaders. Knowledge translation raises awareness of digestive diseases’ impact on society.